Cholesteryl ester transfer protein inhibition and endothelial function: enough with the surrogates
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چکیده
منابع مشابه
Cholesteryl ester transfer protein inhibition and endothelial function: enough with the surrogates.
Statins significantly reduce cardiovascular events in a broad category of patients at risk for or with established atherosclerotic cardiovascular disease; however, a substantial residual risk remains even when LDL-cholesterol (LDL-C) levels are lowered to 70 mg/dL. A part of this residual risk is related to low HDL-C levels. Epidemiological studies, the known favourable biological actions of HD...
متن کاملCholesteryl ester transfer protein inhibition enhances endothelial repair and improves endothelial function in the rabbit.
OBJECTIVE High-density lipoproteins (HDLs) can potentially protect against atherosclerosis by multiple mechanisms, including enhancement of endothelial repair and improvement of endothelial function. This study asks if increasing HDL levels by inhibiting cholesteryl ester transfer protein activity with the anacetrapib analog, des-fluoro-anacetrapib, enhances endothelial repair and improves endo...
متن کاملPlasma cholesteryl ester transfer protein.
The plasma lipoproteins are continuously remodeled during their transit through the plasma compartment, owing to the action of lipid metabolizing enzymes and lipid transfer processes. These activities have a major effect on the composition, size, and concentration of the lipoproteins. Lipid transfer processes involving neutral lipids and phospholipids are mediated by specialized plasma proteins...
متن کاملCholesteryl Ester Transfer Protein Inhibition Is Not Yet Dead--Pro.
Cholesteryl ester transfer protein (CETP) transfers cholesteryl esters from nonatherogenic high-density lipoproteins to potentially proatherogenic non-high-density lipoprotein fractions. Human genetic studies and human cohort studies have concluded that CETP gene polymorphisms associated with decreased CETP activity are accompanied by a significantly lower risk of atherosclerotic cardiovascular...
متن کاملCholesteryl ester transfer protein inhibition: effect on reverse cholesterol transport?
Statins, inhibitors of the key enzyme in the biosynthesis of cholesterol (ie, 3-hydroxy-3-methylglutaryl [HMG]coenzyme A [CoA] reductase), are widely used as the prevailing strategy to combat atherosclerosis through reducing LDL cholesterol levels. Large-scale clinical trials have shown that statins markedly reduce coronary events.1,2 A meta-analysis of 22 studies enrolling nearly 70 000 indivi...
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ژورنال
عنوان ژورنال: European Heart Journal
سال: 2012
ISSN: 0195-668X,1522-9645
DOI: 10.1093/eurheartj/ehs040